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. 2012 Feb 2;103(4):700–707. doi: 10.1111/j.1349-7006.2012.02200.x

Figure 1.

Figure 1

Reduced B16F1 colony formation in thromboxane prostanoid receptor knockout mice (TP −/−). (a) The number of colonies in the lung 21 days after intravenous injection of B16F1 cells. Data are means ± SD for the number of mice (n = 10). *P < 0.05 vs wild‐type mice (WT; Student's t‐test). (b) Typical hematoxylin–eosin staining of the metastatic lung tumors from WT and TP −/− 21 days after intravenous injection of B16F1 cells. Red arrows show the metastatic area. Bar, 250 μm. (c) Mortality rate after intravenous injection of B16F1 cells in WT (n = 20) and TP −/− (n = 20). The number of surviving animals was measured every week until 6 weeks post‐administration. Survival curves were generated using Kaplan–Meier analysis.