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. 2012 Feb 2;103(4):700–707. doi: 10.1111/j.1349-7006.2012.02200.x

Figure 2.

Figure 2

Platelets enhance tumor metastasis. (a) Time course of changes in platelet counts after intravenous injection of B16F1 cells. Data are means ± SD for the number of mice (all n = 10). *P < 0.05 vs wild‐type mice (WT; Student's t‐test). (b) Effect of platelet infusion on the number of colonies formed in the lung 21 days after the injection of B16F1 cells. Data are means ± SD for the number of mice (all n = 10). *P < 0.05 vs PBS‐treated mice (Student's t‐test). (c) Bleeding times were prolonged in thromboxane prostanoid receptor knockout mice (TP −/−). Data are means ± SD for the number of mice (n = 5). *P < 0.05 vs WT (Student's t‐test). (d) The effect of platelets accumulation on colony formation in the lung at 7 and 14 days. Platelets (red) were attached around B16BL‐6 cells (green) in WT, but not in TP −/−.