Figure 7.

Role of thromboxane prostanoid receptor (TP) signaling in the enhancement of tumor colony formation. TP signaling regulates the P‐selectin‐mediated adhesion of activated platelets to P‐selectin glycoprotein ligand‐1 (PSGL‐1) on metastatic tumor cells and endothelial cells, and induce colony formation. Vascular endothelial growth factor (VEGF) and stromal‐derived factor (SDF)‐1 delivered from accumulated platelets induce the mobilization and recruitment of hemangiocytes expressing CXCR4 and VEGFR1 in the lung tissues.