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. 2012 Sep 25;103(11):1929–1937. doi: 10.1111/j.1349-7006.2012.02409.x

Figure 3.

Figure 3

Effect of SB365 on angiogenesis of Huh‐7 hepatocellular carcinoma cells and HUVEC. (A) Inhibition of HUVEC proliferation by SB365. **P < 0.01, compared to control. (B) Production of vascular endothelial growth factor (VEGF) by SB365 in hypoxia‐induced Huh‐7 cells. Data represent mean ± SD from the triplicate wells. (C) Expression of hypoxia‐inducible factor‐1α (HIF‐1α) and VEGF by SB365 in hypoxia‐induced Huh‐7 cells (CoCl2, 100 μM). (D) Effects of SB365 on tube formation in vitro. (E) Effects of SB365 on migration in vitro. Data represent mean ± SD from three independent experiments. ## P < 0.01 compared to control. *P < 0.05 and **P < 0.01 compared to CoCl2.