Table 1.

Tax‐specific CTL expansion in adult T‐cell leukemia/lymphoma (ATL) patients

Patient number	Clinical subtype	ATL status at blood sampling	Total cells (number)		Tax tetramer + cells/lymphocytes (%)		Tax tetramer + cells (number)		Expansion rate†
			Day 0	Day 14	Day 0	Day 14	Day 0	Day 14
Patient 1	Acute	Complete remission	4.5 × 106	9.5 × 106	0.01	4.51	4.5 × 102	4.28 × 105	951.1
Patient 2	Acute	Complete remission	3.0 × 106	2.8 × 106	<0.01	10.02	<3.0 × 102	2.81 × 105	936.7
Patient 3	Chronic	Complete remission	8.6 × 106	1.5 × 107	0.02	9.02	1.72 × 103	1.35 × 106	784.9
Patient 4	Lymphoma	Complete remission	7.5 × 106	1.1 × 107	0.06	10.92	4.5 × 103	1.02 × 106	226.7
Patient 5	Acute	Complete remission	3.0 × 106	1.0 × 107	0.03	0.15	9.0 × 102	1.50 × 104	16.7
Patient 6	Lymphoma	Complete remission	4.3 × 106	3.5 × 106	<0.01	0.62	<4.3 × 102	2.17 × 104	>50.5
Patient 7	Chronic	Watchful waiting	2 × 107	1.0 × 108	1.32	12.50	2.64 × 105	1.25 × 107	47.3
Patient 8	Chronic	Watchful waiting	6.5 × 106	9.2 × 106	0.01	7.05	6.5 × 102	6.49 × 105	998.5
Patient 88′‡	Acute	Before treatment	5.26 × 106	5.5 × 106	0.02	0.02	1.05 × 104	1.10 × 104	1.05
Patient 88″‡	Acute	Partial remission	3.5 × 106	6.8 × 106	0.06	26.36	2.1 × 103	1.79 × 106	852.4
Patient 9	Smoldering	Under systemic phototherapy for skin	3.0 × 106	5.8 × 106	0.02	28.78	6.0 × 102	1.67 × 106	2783.3
Patient 10	Lymphoma	Initially diagnosed	7.3 × 106	1.2 × 107	<0.01	0.28	<7.3 × 102	3.36 × 104	>46.0
Patient 11	Acute	Initially diagnosed	4.3 × 106	4.1 × 106	<0.01	0.14	<4.3 × 102	5.74 × 103	>13.3
Patient 12	Acute	Initially diagnosed	5.2 × 106	ND	ND	ND	ND	ND	ND
Patient 13	Acute	Initially diagnosed	1.0 × 107	ND	ND	ND	ND	ND	ND
Patient 14	Acute	Diagnosed as relapse with acute type phenotype	6.0 × 106	7.0 × 106	0.01	0.03	6.0 × 102	2.10 × 103	3.5
Patient 14 (CD4‐subset)§			6.0 × 106	2.6 × 106	0.01	3.79	6.0 × 102	9.90 × 104	165.0

†Cell numbers of Tax tetramer + cells on day 14 was divided by that of day 0. ‡Patient 8 progressed from chronic to acute subtypes, and then he received allogeneic hematopoietic stem cell transplantation. §CD4+ cells were depleted on day 4. ATL, adult T‐cell leukemia/lymphoma; CTL, cytotoxic T lymphocytes; HTLV‐1, human T‐lymphotropic virus type‐1; ND, not detected.