Table 4. Statistical analysis of PK parameters of perampanel after single-dose administrations of 4-mg fine granules and 4-mg tablet (PK analysis set).
| PK parameter |
Geometric means | Geometric mean ratio (%) (test : reference) | 90% CIs (%) (lower, upper) | |
|---|---|---|---|---|
| 4-mg fine granules (test) (N = 21) | 4-mg tablet (reference) (N = 21) | |||
| Cmax (ng/mL) | 149 | 149 | 100 | 90.8, 110 |
| AUC(0–168h) (ng×h/mL) | 5,630 | 5,420 | 105 | 98.2, 112 |
AUC(0–168h) = area under the concentration–time curve from time zero to 168 hours; CI = confidence interval; Cmax = maximum observed concentration; PK = pharmacokinetic.