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The genetic interaction between Ras and RB. The Ras signal induces RB protein (pRB) phosphorylation by upregulating cyclin D1; this constitutes one of primary mechanisms by which mitogenic signals control the cell cycle. Inversely, RB status can influence Ras activation status by regulating sterol regulatory element‐binding protein (SREBP) and isoprenylation‐related genes. Thereby, Ras mediates pRB function to control the indicated biological events.
