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. 2020 Nov 11;10:19606. doi: 10.1038/s41598-020-76456-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intrinsic membrane properties of nAc dissociated neurons in WT and 2xTg mice. (a) Representative traces of current-clamp recordings after injecting 0, 25 and 50 pA current steps for WT (grey) and 2xTg mice (blue). (b) Relationship between the number of spikes generated and the injected current intensity for both conditions (F(1,123) = 12.1639, p = 1.38E-9; post-hoc test: with 25 pA, WT vs. 2xTg, p = 1.30E-3; with 50 pA, WT vs 2xTg, p = 7.5E-3). (c) Quantification of Rheobase constant (t(22) = 5.475, p = 1.67E-4), (d) input resistance (t(22) = 0.029, p = 0.97684) and action potential parameters: (e) amplitude (t(22) = 2.226, p = 0.036),(f) threshold (t(22) = 2.835, p = 0.009) and (g) half-width (t(22) = -0.894, p = 0.380). Scatter and bars graphs represent the average ± SEM. *denotes p < 0.05, **p < 0.01, *** p < 0.001 (unpaired Student’s t-test for (c–f) and (g) and two-way ANOVA with Holm-Sidak’s post-hoc test for (b). Number of neurons: WT = 9 and 2xTg = 15. Neurons obtained in at least 4 independent experiments. Number of mice: WT = 5 and 2xTg = 4.