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. 2020 Nov 11;10:19606. doi: 10.1038/s41598-020-76456-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations of spontaneous excitability in isolated nAc neurons in 2xTg mice. (a) Membrane potential (Vm) recordings of 3 representative neurons for WT (grey) and 2xTg (blue). (b) Percentage of cells that exhibited spontaneous overshooting spikes during the recordings (χ²(1,30) = 6.211, p = 0.126). (c) Quantification of firing frequency of neurons that exhibited spontaneous spikes (U = 60, z-score = − 2.092, p = 0.0366). (d) Average Vm SD values for the different experimental conditions (t(28) = − 0.840, p = 0.407). Bar graphs represent the average ± SEM. *denotes p < 0.05 and ***p < 0.001 (Chi-square test for (b), Mann–Whitney-test for (c) and unpaired Student’s t-test for (d). Number of cells: WT = 17 and 2xTg = 13. Neurons obtained in at least 4 independent experiments. Number of mice: WT = 5 and 2xTg = 4.