Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 11;10:19606. doi: 10.1038/s41598-020-76456-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Decreased excitatory and inhibitory post-synaptic receptors in the nAc of 2xTg. (a-c) Representative post-synaptic currents evoked by extracellular application of AMPA 100 µM (a), GABA 100 µM (b) and Glycine (Gly) 1000 µM (c) in WT and 2xTg mice. Segmented lines in red indicate the level of the maximum current reached (I_MAX). (d-g) Quantification of the amplitude of the average evoked current (I_MAX) by AMPA (d) (U = 209, z-score = -3.687, p = 1.1E-4), GABA (e) (U = 411, z-score = -0.564, p = 0.287) and Gly (f) (U = 144, z-score = -1.911, p = 0.028), as well as the percentage of neurons responding to Gly 1000 µM (g) (χ²(1,62) = 0.1356, p = 0.7126). Boxes indicate interquartile range (IQR); center lines, median; whiskers, 1.5 × IQR (interquartile range). * denotes p < 0.05, *** p < 0.001 (two-tailed Mann–Whitney test for (d–f) and Chi-square test for (g). Responding neurons for AMPA: WT (n = 26) and 2xTg (n = 36). GABA: WT (n = 32) and 2xTg (n = 36). Gly: WT (n = 21) and 2xTg (n = 21). Neurons obtained in at least 4 independent experiments (5 mice for WT and 4 mice for 2xTg).