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. 2012 Oct 10;103(11):2027–2037. doi: 10.1111/j.1349-7006.2012.02412.x

Figure 6.

Figure 6

Involvement of CCL2 in the development of fenestrated capillaries of VHL −/− clear cell renal cell carcinomas. (A) Effects of CCL2 neutralizing antibody (CCL2 Ab) treatment on microvasculature. Representative data are shown. CD31, scale bars = 100 μm; scanning electron micrographs (SEM), scale bars = 1 μm. Bottom left, 786‐O xenograft tumors in CCL2 Ab treatment group showed significant reduction in microvessel density compared to those in vehicle treatment group (CTR). Bottom right, quantitation of endothelial fenestrations in capillaries after treatment with CCL2 Ab. Columns, mean; bars, SE. (B) Expression of CCL2 in tumors with or without VHL mutation. Top, representative pictures of immunohistochemistry sections of tumors showing none, weak, or strong staining for CCL2. Bottom, ratio of CCL2 expression pattern and correlation of VHL status.