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. 2012 Feb 3;103(4):813–820. doi: 10.1111/j.1349-7006.2011.02199.x

Figure 2.

Figure 2

Expression of zinc finger E‐box binding homeobox 1 (ZEB1) and epithelial–mesenchymal transition (EMT) markers in colorectal carcinoma (CRC) samples. (A) The ZEB1 expression (black arrows) in the vasculogenic mimicry (VM)‐positive group was higher than in the VM‐negative group. In contrast, except for some stromal cells (red arrows), tumor cells in the VM‐negative group showed almost no ZEB1 expression (immunohistochemical staining, ×400). (B) E‐cadherin expression was lower in the ZEB1‐positive CRC tissue samples than in the ZEB1‐negative ones. Some tumor cells showed vimentin expression in ZEB1‐positive CRC samples (black arrow), whereas the tumor cells showed no vimentin expression and only some stromal cells showed vimentin expression (red arrow) in ZEB1‐negative CRC samples (IHC staining, ×400).