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. 2020 Nov 11;40(46):8913–8923. doi: 10.1523/JNEUROSCI.1163-20.2020

Figure 5.

Figure 5.

Relationships between visual system white matter fractional anisotropy (FA) and estimates of visual system processing abilities. A, Representative probability map of voxels belonging to commissural visual cortex connectivity overlaid on a T1-weighted MRI in sagittal, coronal, and horizontal planes. B, The same probability map overlaid on a FA map pseudocolored in copper. C, Box and whisker plots of commissural visual white matter FA estimates for each individual monkey. Boxes represent the middle 50% of the data, and horizontal lines mark the median of each distribution. Each filled circle indicates an individual monkey, with black circles representing adult animals and gray circles representing the aged. Commissural visual white matter FA was not different between adult and aged monkeys. D, Relationship between commissural visual white matter FA and estimates of visual system function (visual evoked potential (VEP) latency differences to light presented at 2 and 1 Hz). In all scatterplots, solid trend lines represent significant relationships and dotted trend lines represent nonsignificant relationships. There was a significant negative relationship between commissural visual white matter FA and VEP latency differences. Note that lower VEP latency differences are thought to correspond to better visual function. E, Representative probability map of voxels belonging to optic thalamic radiation connectivity overlaid on a T1-weighted MRI. F, The same probability map overlaid on a FA map pseudocolored in copper. G, Box and whisker plots of optic radiation FA estimates for each individual monkey separated by left and right hemisphere. Aged monkeys had significantly lower optic radiation FA estimates than did the adult animals. H, Relationship between optic radiation FA and estimates of visual system processing abilities. Triangles represent left hemisphere optic radiation FA estimates, whereas circles represent FA estimates from the right hemisphere optic radiation. A significant negative relationship was observed between right hemisphere optic radiation FA and visual system function. **p < 0.01.