Figure 6.

Four Analyses That Contributed to the CKI

The x axis contains all kinase names in the analysis, while the y axis represents the TCGA cancer. The plot on the top of the graph shows how many cancers a particular kinase is “significant” in. The plot on the right side of the graph represents how many significant kinases a particular cancer has for this analysis.

(A) 424 kinases are differentially overexpressed in at least two cancers.

(B) 317 kinases are prognostic of survival in at least two cancers.

(C) Many kinases have expressions that correlate with T, N, and M staging. This heat-map quantifies the extent to which each kinase correlates with the clinical outcome, TNM staging (total score out of 3, max score of 1 per parameter)

(D) 13 kinases have significant hotspot mutations in at least two cancers. See also Table S7.