REAGENT or RESOURCE	SOURCE	IDENTIFIER
Deposit Data
Raw RNAseq data	This study	EGAS00001004707
Antibodies
anti-human CD8 Pacific blue (RPA-T8)	BioLegend	Cat# 301023; RRID:AB_493110
anti-human CD103-FITC (Ber-ACT8)	BioLegend	Cat# 350204; RRID:AB_10639865
anti-human KLRG1-PE (13F12F2)	ebioscience	Cat# 12-9488-42; RRID:AB_2572716
anti-human CD3-Alexa700 (UCHT1)	BioLegend	Cat# 300424; RRID:AB_493741
anti-human CD69-APC-Cy7 (FN50)	BioLegend	Cat# 310914; RRID:AB_314849
anti-human granzyme-B-FITC (GB11)	BioLegend	Cat#515403; RRID:AB_2114575
anti-human TNFα-PE/Dazzle594 (Mab11)	BioLegend	Cat# 502945; RRID:AB_2564172
anti-human Aiolos-Alexa488 (16D9C97)	BioLegend	Cat# 371107; RRID:AB_2616975
anti-human Vα7.2-APC-Cy7 (3C10)	BioLegend	Cat# 351713; RRID:AB_2561995
anti-human CD161-Alexa488 (HP-3G10)	BioLegend	Cat# 339923; RRID:AB_2563938
anti-human TCF-1-PE (7F11A10)	BioLegend	Cat#655207; RRID:AB_2728491
anti-human 4-1BB-PE-Dazzle594 (clone 4B4-1)	BioLegend	Cat#309825; RRID:AB_2566259
anti-human TCRγδ-PerCPCy5.5 (B1)	BioLegend	Cat# 331223; RRID:AB_2563012
anti-human CD103-BV711 (Ber-ACT8)	BD Biosciences	Cat# 563162; RRID:AB_2738039
anti-human CD49-PerCPefluor710 (TS2/7)	Thermo Fisher Scientific	Cat# 46-9490-41; RRID:AB_2573890
anti-human S1PR1-efluor660 (SW4GYPP)	Thermo Fisher Scientific	Cat# 50-3639-41; RRID:AB_2574207
anti-human PD-1-PeCyanine7 (eBioJ105)	Thermo Fisher Scientific	Cat# 25-2799-42; RRID:AB_10853804
anti-human AHR-PerCPefluor710 (FF3399)	Thermo Fisher Scientific	Cat# 46-9854-41; RRID:AB_2573905
anti-human Ki67-PerCPefluor710 (20Raj1)	Thermo Fisher Scientific	Cat# 46-5699-41; RRID:AB_10804404
anti-human IFNγ-APC (B27)	BD Biosciences	Cat# 554702; RRID:AB_398580
anti-human Hobit-Alexa647 (Sanquin-Hobit/1)	BD Biosciences	Cat# 566250; RRID:AB_2739629
anti-human CD45RA-APC (T6D11)	Miltenyi Biotec	Cat#130-098-187; RRID:AB_2660978
anti-human pSTAT3pS727-APC (REA324)	Miltenyi Biotec	Cat# 130-105-000; RRID:AB_2653576
anti-human CD39-APC (MZ18-23C8)	Miltenyi Biotec	Cat#130-100-459; RRID:AB_2660867
anti-human IL17A-PeVio770	Miltenyi Biotec	Cat#130-100-327; RRID:AB_2659809
anti-human/mouse Tbet-APC (REA102)	Miltenyi Biotec	Cat# 130-119-821; RRID:AB_2784465
mouse anti-human phospho-tyrosine (PY20)	BD Biosciences	Cat# 610000; RRID:AB_397423
rabbit anti-human CD8	Thermo Fisher Scientific	Cat#PA1-37298; RRID:AB_2075396
Goat anti-mouse IgG AlexaFluor-488	Thermo Fisher Scientific	Cat# A-11001; RRID:AB_2534069
Goat anti-rabbit AlexaFluor-647	Thermo Fisher Scientific	Cat# A-21244; RRID:AB_2535812
anti-human Pan-keratin (clones AE1/AE3)	Agilent	Cat# M3515; RRID:AB_2132885
IHC anti-human CD8 (clone SP16)	Spring Bioscience	Cat#M3164; RRID:AB_1660846
IHC anti-human CD103 (clone EPR4166-2)	Abcam	Cat#ab129202; RRID:AB_11142856
anti-human ICAM-1 (clone N1C2)	GeneTex	Cat#GTX100450; RRID:AB_1950536
anti-human E-cadherin (clone EP6)	BioSB	Cat#BSB5466
LEAF Purified anti-human CD3 antibody (OKT3)	BioLegend	Cat#317304; RRID:AB_571925
Purified anti-human CD28 antibody (CD28.2)	BioLegend	Cat#302901; RRID:AB_314303
Biological Samples
Resected lung tumors and adjacent healthy lung tissue samples	Institut mutualiste Montsouris and the Hôpital Marie-Lannelongue	See Tables S1 and S4 for details
Human healthy blood	Établissement français du sang, Paris, France	N/A
Chemicals, Peptides, and Recombinant Proteins
Phorbol 12-myristate 13-acetate (PMA)	Sigma-Aldrich	Cat#P1585
ionomycine	Sigma-Aldrich	Cat#10634
recombinant IL-2	Sanofi recherche	Cat#1A1
recombinant human TGF-β1	R&D Systems	Cat#240-B-002
recombinant human IL-6	Miltenyi Biotec	Cat# 130-095-365
BrefeldinA	Thermo Fisher Scientific	Cat#00-4506-51
Chromium-51 Radionuclide	Perkin Elmer	Cat#NEZ030005MC
Critical Commercial Assays
CD8 Microbeads, human	Miltenyi Biotec	Cat#130-045-201
Tumor cells Isolation Kit, human	Miltenyi Biotec	Cat#130-108-339
Human Tumor dissociation kit	Miltenyi Biotec	Cat#130-095-929
Foxp3/Transcription Factor Staining Buffer Set	Thermo Fisher Scientific	Cat#00-5523-00
Single cell RNA purification kit	Norgen	Cat#51800
SureSelect Automated Strand-Specific RNA Library Preparation Kit	Agilent	Cat#G9691A
QIAamp DNA micro kit	QIAGEN	Cat#56304
Maxima first strand cDNA synthesis kit	Thermo-Fischer Scientific	Cat#K1641
Maxima SYBR Green Master Mix	ThermoFischer Scientific	Cat#4472908
LIVE/DEAD Fixable UV dead cell stain kit	ThermoFischer	Cat#L34962
Human IL-17A ELISA Kit	Biotechne	Cat#DY317-05
Opal 7-color Automation IHC Kit	Akoya/Perkin Elmer	NEL801001KT
Oligonucleotides
Primer sequences for IKZF3, RORC,AHR, IL17A, TCF7, S1PR1 and 18S	This paper; See Table S10	N/A
Software and Algorithms
GraphPad Prism software V8	GraphPad Software Inc.	RRID:SCR_002798
FlowJo V10	Tree Star Inc	RRID: SCR_008520
RStudio software	The R Foundation	RRID:SCR_000432
InForm software	Akoya/PerkinElmer	N/A
R (v 3.2.3)	The R Foundation	RRID: SCR_001905
FastQC (v 0.11.3)	Babraham bioinformatics	RRID:SCR_014583
Salmon (v 0.8.2)	55	N/A
sleuth (v 0.28.1)	56	RRID:SCR_002555
clusterProfiler (v 3.8.0)	57	RRID:SCR_016884
MiXCR (v 2.1.10)	58	RRID:SCR_018725
KEGG pathway	https://www.genome.jp/kegg-bin/show_pathway?hsa04660	RRID:SCR_012773
ImmunoSEQ Analyzer Platform Adaptive Biotechnologie	Adaptive Biotechnologie	RRID:SCR_014709