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. 2020 Jul 21;1(4):100060. doi: 10.1016/j.xcrm.2020.100060

Figure 5.

Figure 5

Function and TCR Expression of HBV-Specific TCR-Redirected T Cells of Healthy and HBV/HDV Chronically Infected Subjects

(A) Schematic illustrating HBV-specific TCR T cells produced in vitro from HBV/HDV patient (PTX) PBMCs.

(B) Dot plots show the representative expression of indicated TCR on T cells of HBV/HDV-co-infected patients measured with the respective dextramers (left panel). The frequency of dextramer+ CD8+ T cells are indicated in the center panel. Graph bars depict the mean frequency of IFN-γ+ and TNF-α+ CD8+ cells out of the total CD8+ T cells obtained by ICS. HBV-TCR T cells were incubated with HLA-A02+ HepG2 cells pulsed or unpulsed with the corresponding peptide (HBV peptide 183-91 and HBV peptide 370-79).

Each dot represents a single individual (6 donors from each group; healthy control and HBV/HDV patients tested for HBs183 TCR-T cells and 2 donors from each group tested for HBs 370-TCR). Non-significant p values are indicated as N.S.