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. 2020 Sep 24;219(10):e202008130. doi: 10.1083/jcb.202008130

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© 2020 Matikainen et al.

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Figure 1. — NLRP3 inflammasome drives exosomal miRNA loading. Virus infection and ATP stimulation activates the NLRP3 inflammasome, leading to proteolytic processing of caspase-1. Activated caspase-1 in turn cleaves RILP. cRILP interacts with FMRP and with Hrs, a component of the ESCRT-0 complex. RNA-binding protein FMRP acts as a chaperone to package specific AAUGC motif–containing miRNAs into the intraluminal vesicles, which is followed by secretion of miRNA-loaded exosomes.