Table 1.
Summary of differentially expressed genes associated with extracellular matrix structural constituent (GO:0005201) and showed positive associations to cancer invasiveness and metastasis in the transcriptome of urothelial carcinoma of urinary bladder (GSE31684).
| Probe | Comparing T2-4 to Ta-T1 | Comparing meta. to non-meta.# | Gene symbol | Gene title | Molecular function | ||
|---|---|---|---|---|---|---|---|
| Log ratio | p-value | log ratio | p-value | ||||
| 203886_s_at | 0.8918 | 0.0003 | 0.6266 | 0.0009 | FBLN2 | Fibulin 2 | Calcium ion binding, extracellular matrix structural constituent, protein binding |
| 204163_at | 1.1047 | <0.0001 | 0.6313 | 0.0001 | EMILIN1 | Elastin microfibril interfacer 1 | Extracellular matrix constituent conferring elasticity, extracellular matrix structural constituent, identical protein binding, protein binding |
| 205648_at | 0.6169 | 0.0014 | 0.4056 | 0.0061 | WNT2 | Wingless-type MMTV integration site family member 2 | Extracellular matrix structural constituent, signal transducer activity |
| 205713_s_at | 1.8386 | <0.0001 | 1.1823 | 0.0001 | COMP | Cartilage oligomeric matrix protein | Calcium ion binding, extracellular matrix structural constituent, protein binding |
| 209082_s_at | 0.6536 | 0.0015 | 0.4516 | 0.0042 | COL18A1 | Collagen; type XVIII; alpha 1 | Extracellular matrix structural constituent, metal ion binding, protein binding, structural molecule activity, zinc ion binding |
| 209156_s_at | 2.1304 | <0.0001 | 0.9732 | 0.0021 | COL6A2 | Collagen; type VI; alpha 2 | Extracellular matrix structural constituent, protein binding, protein binding; bridging, structural molecule activity |
| 209356_x_at | 0.5664 | 0.0027 | 0.4818 | 0.0008 | EFEMP2 | EGF-containing fibulin-like extracellular matrix protein 2 | Calcium ion binding, extracellular matrix structural constituent, protein binding, transmembrane receptor activity |
| 209758_s_at | 1.4195 | <0.0001 | 0.5778 | 0.0087 | MFAP5 | Microfibrillar associated protein 5 | Extracellular matrix structural constituent |
| 213290_at | 0.832 | 0.0002 | 0.5142 | 0.004 | COL6A2 | Collagen; type VI; alpha 2 | Extracellular matrix structural constituent, protein binding, protein binding; bridging, structural molecule activity |
| 213764_s_at | 1.8425 | <0.0001 | 0.8102 | 0.0034 | MFAP5 | Microfibrillar associated protein 5 | Extracellular matrix structural constituent |
| 214702_at | 0.8698 | <0.0001 | 0.3948 | 0.0100 | FN1 | Fibronectin 1 | Collagen binding, extracellular matrix structural constituent, heparin binding, protein binding |
| 215076_s_at | 1.4494 | <0.0001 | 0.5177 | 0.0031 | COL3A1 | Collagen; type III; alpha 1 (Ehlers-Danlos syndrome type IV; autosomal dominant) | Extracellular matrix structural constituent, structural molecule activity |
| 221900_at | 0.8558 | <0.0001 | 0.3936 | 0.0014 | COL8A2 | Collagen; type VIII; alpha 2 | Extracellular matrix structural constituent, protein binding, protein binding; bridging, structural molecule activity |
#
Meta., distal metastasis developed during follow-up; Non-Meta.: no metastatic event developed.