Table 2.

Correlations between FBLN2 expression and other important clinicopathological parameters in urothelial carcinomas.

Parameter	Category	Upper urinary tract urothelial carcinoma				Urinary bladder urothelial carcinoma
		Case No.	FBLN2 expression		p-value	Case No.	FBLN2 expression		p-value
			Low	High			Low	High
Gender	Male	158	77	81	0.664	216	107	109	0.868
	Female	182	93	89		79	40	39
Age (years)	<65	138	73	65	0.377	121	55	66	0.210
	≥65	202	97	105		174	92	82
Tumor location	Renal pelvis	141	64	77	0.228	–	–	–	–
	Ureter	150	77	73		–	–	–	–
	Renal pelvis and ureter	49	29	20		–	–	–	–
Multifocality	Single	278	135	143	0.261	–	–	–	–
	Multifocal	62	35	27		–	–	–	–
Primary tumor (T)	Ta	89	63	26	<0.001*	84	62	22	<0.001*
	T1	92	57	35		88	44	44
	T2–T4	159	50	109		123	41	82
Nodal metastasis	Negative (N0)	312	165	147	<0.001*	266	141	125	0.001*
	Positive (N1–N2)	28	5	23		29	6	23
Histological grade	Low grade	56	44	12	0.001*	56	38	18	0.003*
	High grade	284	126	158		239	109	130
Vascular invasion	Absent	234	144	90	<0.001*	246	138	108	<0.001*
	Present	106	26	80		49	9	40
Perineural invasion	Absent	321	168	153	<0.001*	275	144	131	0.001*
	Present	19	2	17		20	3	17
Mitotic rate (per 10 high-power fields)	<10	173	104	69	<0.001*	139	85	54	<0.001*
	≥10	167	66	101		156	62	94

^*Statistically significant.