. 2020 Oct 29;10:570340. doi: 10.3389/fonc.2020.570340

Table 4.

Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in urinary bladder urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific survival					Metastasis-free survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	RR	95% CI	p-value	No. of event	p-value	RR	95% CI	p-value
Gender	Male	216	41	0.4446	–	–	–	60	0.2720	–	–	–
	Female	79	11		–	–	–	16		–	–	–
Age (years)	<65	121	17	0.1136	–	–	–	31	0.6875	–	–	–
	≥65	174	35		–	–	–	45		–	–	–
Primary tumor (T)	Ta	84	1	<0.0001^*	1	–	<0.001^*	4	<0.0001^*	1	–	0.006^*
	T1	88	9		4.908	0.532–45.247		23		3.922	1.132–13.597
	T2–T4	123	42		22.382	2.587–193.647		49		6.639	1.943–22.693
Nodal metastasis	Negative (N0)	266	41	0.0002^*	1	–	0.489	61	<0.0001^*	1	–	0.060
	Positive (N1–N2)	29	11		1.283	0.634–2.598		15		1.816	0.975–3.381
Histological grade	Low grade	56	2	0.0013^*	1	–	0.911	5	0.0007^*	1	–	0.907
	High grade	239	50		1.094	0.226–5.282		71		0.937	0.316–2.782
Vascular invasion	Absent	246	37	0.0024^*	1	–	0.121	54	0.0001^*	1	–	0.845
	Present	49	15		0.581	0.293–1.155		22		0.941	0.513–1.727
Perineural invasion	Absent	275	44	0.0001^*	1	–	0.075	66	0.0007^*	1	–	0.252
	Present	20	8		2.122	0.927–4.854		10		1.531	0.739–3.174
Mitotic rate (per 10 high-power fields)	<10	139	12	<0.0001^*	1	–	0.023^*	23	<0.0001^*	1	–	0.050^*
FBLN2 expression	≥ 10	156	40		2.190	1.115–4.305		53		1.677	0.999–2.815
	Low	147	12	0.0001^*	1	–	0.014^*	17	<0.0001^*	1	–	0.001^*
	High	148	40		2.306	1.185–4.489		59		2.493	1.427–4.353

Statistically significant.