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. 2020 Oct 22;21(21):7820. doi: 10.3390/ijms21217820

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antibody-mediated FcR activation of neutrophils. Neutrophils express various FcRs that are either activating or inhibitory, thereby respectively stimulating or repressing neutrophil-mediated antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), and trogocytosis. Among the activation receptors are the immunoglobulin G (IgG)-binding FcRs; CD64, CD32a and CD16a. In addition, neutrophils express the immunoglobulin A (IgA)-binding FcR CD89. Inhibitory IgG-binding FcRs that are expressed by neutrophils comprise CD32b and CD16b.