Table 3.

Alteration of coagulation and fibrinolysis factors caused by chronic stress.

Chronic Stress
Parameter	Analyzed Parameter	Stress Domain	Variation
Coagulation	FVIIa	Low SES	↑ [88,89]
		Job stress	↑ [49,90,91]
	FVIIIa	Job stress	↑ [49,90,91]
	Fibrinogen	Low SES	↑ [88,89]
		Job stress	↑ [49,90,91]
	vWF	Caregivers	↑ [92,93,94]
	TAT	Caregivers	↑ [92,93,94]
	D-dimer	Low SES	↑ [88,89]
		Caregivers	↑ [92,93,94]
	% PT	Job stress	= [49,90,91]
	aPTT	Job stress	= [49,90,91]
Fibrinolysis	t-PAa t-PA:Ag PAI-1 activity	Job stress	↓ [49,90,91]
		Caregivers	↑ [9,92,93,94,112]
		Low SES	↑ [88,89]
		Job stress	↑ [49,90,91]
		Caregivers	↑ [92,93,94]

F, factor; a, clotting activity; ag, antigen; vWF, von Willebrand Factor; TAT, thrombin–antithrombin complex; PT, prothrombin time; aPTT, activated partial thromboplastin time; t-PA, tissue-plasminogen activator; PAI-1, plasminogen activator inhibitor-1. ↑, increased; ↓, decreased; =, unvaried.