Table 1.

The comparison between phenobarbital and levetiracetam in neonatal seizure treatment

	First launch	Mechanism of action	Interaction with other drugs	Specific consideration in organ failure	Use during recent decade	Use as monotherapy	Apoptotic feature	Cost
Phenobarbital	1912	CYP2C19	Yes	yes	Decreased	Decreased	Proven	Cheaper
Levetiracetam	1999	SV2A	No	Not necessary	Increased	Increased	In doubt	More expensive