Table 1.
Univariate analysis of the predictors of PrimDC and SecDC in the test cohort
| Parameter | Prim DC versus No DC |
SecDC versus NO DC |
||
|---|---|---|---|---|
| Mean (±SD) or OR (95% CI) | P-value | Mean (±SD) or OR (95% CI) | P-value | |
| Age, years | 52.9 (±12.6) versus 52.9 (±12.6) | 0.0379 | 49.7 (±10.1) versus 52.9 (±12.6) | 0.0008 |
| Sex (female) | 1.11 (0.77–1.6) | 0.5820 | 1.56 (0.94–2.6) | 0.1054 |
| Prior anticoagulation | 0.81 (0.41–1.6) | 0.6244 | 0.67 (0.23–1.98) | 0.6272 |
| Arterial hypertension | 1.2 (0.82–1.75) | 0.3841 | 1.59 (0.91–2.78) | 0.1143 |
| Smoking (history) | 0.88 (0.53–1.46) | 0.7058 | 1.0 (0.51–2.13) | 0.8565 |
| Diabetes mellitus | 0.84 (0.34–2.09) | 0.8265 | 0.34 (0.04–2.53) | 0.5018 |
| Hunt and Hess scale (IV–V) | 4.54 (3.15–6.54) | <0.0001 | 2.46 (1.48–4.08) | 0.0007 |
| Dilated/fixed pupils | 6.08 (3.67–10.06) | <0.0001 | 1.46 (0.55–3.89) | 0.3995 |
| Fisher scale (III–IV) | 30.77 (4.24–223.0) | <0.0001 | 2.17 (0.85–5.58) | 0.1322 |
| Aneurysm (anterior circulation) | 5.74 (3.29–10.02) | <0.0001 | 2.83 (1.45–5.51) | 0.0016 |
| Aneurysm size, mm | 8.7 (±4.8) versus 6.7 (±4.2) | <0.0001 | 8.1 (±5.1) versus 6.7 (±4.2) | 0.0118 |
| Treatment modality (clipping) | 68.14 (32.66 - 142.2) | <0.0001 | 2.05 (1.21–3.46) | 0.0110 |
| Acute hydrocephalus | 0.88 (0.61–1.27) | 0.5096 | 3.67 (1.64–8.18) | 0.0005 |
| Presence of IVH | 1.17 (0.83–1.64) | 0.3865 | 1.48 (0.89–2.46) | 0.1553 |
| Severity of IVH (Graeb score) | 2.89 (±3.8) versus 2.17 (±3.1) | 0.1207 | 2.58 (±3.3) versus 2.17 (±3.1) | 0.1771 |
| Presence of ICH | 20.07 (13.01–30.95) | <0.0001 | 3.88 (2.29–6.56) | <0.0001 |
| ICH volume, ml | 38.86 (±35.2) versus 13.9 (±16.8) | <0.0001 | 13.4 (±16) versus 13.9 (±16.8) | 0.6165 |
| Rebleeding | 3.88 (1.91–7.85) | 0.0004 | 2.79 (0.99–7.87) | 0.0595 |
| Early angiographic vasospasm | 2.76 (1.62–4.69) | 0.0004 | 3.51 (1.91–6.45) | 0.0001 |
| Early Infarction | 2.97 (2.07–4.25) | <0.0001 | 4.22 (2.5–7.11) | <0.0001 |
| WBC, × 109/l | 14.02 (±4.5) versus 13 (±4.7) | 0.0068 | 14.7 (±4.7) versus 13 (±4.7) | 0.0052 |
| Haemoglobin, × 101 g/l | 12.4 (±2) versus 12.7 (±1.9) | 0.1099 | 12.9 (±1.9) versus 12.7 (±1.9) | 0.6074 |
| CRP, × 10−3 g/l | 0.7 (±1.6) versus 1.0 (±1.9) | 0.1504 | 1.0 (±2.1) versus 1.0 (±1.9) | 0.5202 |
| CSF Interleukin-6, × 10−6 g/l | 4.16 (±6.14) versus 3.4 (±6.51) | 0.7950 | 4.39 (±7.3) versus 3.4 (±6.51) | 0.9597 |
| CSF cells, × 106/l | 2705 (±7204) versus 1229 (±2963) | 0.5562 | 1380 (±1853) versus 1229 (±2963) | 0.3275 |
| Troponin-I, 10−9 g/l | 0.6 (±2) versus 2.5 (±31.7) | 0.2435 | 0.5 (±1) versus 2.5 (±31.7) | 0.9254 |
| Maximal systolic BP, mmHg | 161.6 (±22.6) versus 165.4 (±25.8) | 0.0513 | 168.2 (±24.7) versus 165.4 (±25.8) | 0.2476 |
| Minimal systolic BP, mmHg | 125.5 (±88.6) versus 124.1 (±57.4) | 0.2574 | 122.9 (±24.2) versus 124.1 (±57.4) | 0.9612 |
| Mean MAP, mmHg | 89.3 (±14.8) versus 90.5 (±14.6) | 0.1131 | 93.1 (±15.3) versus 90.5 (±14.6) | 0.2552 |
| Maximal body temperature, °C | 37.2 (±0.9) versus 37 (±1.9) | 0.5385 | 37.2 (±0.9) versus 37 (±1.9) | 0.3009 |
For laboratory parameters, the first value at admission was considered. P-values set in boldface indicate statistical significance.
SD = standard deviation; OR = odds ratio; CI = confidence interval; WBC = white blood cells; CRP = C-reactive protein; CSF = cerebrospinal fluid; BP = blood pressure; MAP = mean arterial pressure.