Table 3:

Outstanding questions

- By which mechanism does H1.5T10 phosphorylation counteract Ras-mediated carcinogenesis?

- How is H1.5 expression regulated? How is it regulated by sex-hormones?

- What are physiological-binding patterns of H1.5 in various tissues? How do they change during cell differentiation and transformation?

- What is the role of H1.5 in silencing transposable elements in mammals?

- What role does the local chromatin landscape play in H1.5 binding?

- Which chromatin modifiers can be recruited by H1.5?

- Do aberrant H1.5 levels affect alternative splicing events that are relevant for tumorigenesis?