. 2020 Sep 27;6(1):dvaa010. doi: 10.1093/eep/dvaa010

Table 2:

Differentially methylated F1 genes involved in the endocrine system, drug metabolism, histone modifications, or DNA methylation

Gene symbol	Gene name	DMRs	DMSs
Endocrine
esr1^a	Estrogen receptor 1	1 ↓	1 ↓
esr2a^b	Estrogen receptor2a	2 ↓	0
esr2b^b	Estrogen receptor 2b	5 ↓	0
hsd17b10^a	Hydroxysteroid (17-beta) dehydrogenase 10	1 ↑, 3 ↓	1 ↑, 1 ↓
mdm2^a	MDM2 proto-oncogene	4 ↓	2 ↓
nr5a2^b	Nuclear receptor subfamily 5, group A, member 2	4 ↑, 5 ↓	0
ncoa4^a	Nuclear receptor coactivator 4	3 ↑, 1 ↓	1 ↑
Xenobiotic metabolism
ahr1a^b	Aryl hydrocarbon receptor 1a	2 ↑	0
ahr1b^a	Aryl hydrocarbon receptor 1b	1 ↑, 2 ↓	2 ↓
ahr2^a	Aryl hydrocarbon receptor 2	1 ↑, 6 ↓	3 ↑, 2 ↓
Histone modification
setd7^a	SET domain containing 7, histone lysine methyltransferase	1 ↑	1 ↑
jak2a^b	Janus kinase 2a	3 ↑	0
jak2b	Janus kinase 2b	0	1 ↑
rbl1^a	Retinoblastoma-like 1	1 ↑, 2 ↓	2 ↑
rcor1^a	REST corepressor 1	3 ↓	1 ↓
taf6l	TAF6-like RNA polymerase II	0	2 ↑
mrgbp^a	MRG/MORF4L-binding protein	4 ↑, 6 ↓	2 ↑
brpf1^b	Bromodomain and PHD finger containing, 1	2 ↑, 3 ↓	0
carm1^b	Coactivator-associated arginine methyltransferase 1	2 ↓	0
ehmt2^b	Euchromatic histone-lysine N-methyltransferase 2	2 ↓	0
hmga2^b	High mobility group AT-hook 2	1 ↓	0
kdm5bb^b	Lysine (K)-specific demethylase 5Bb	2 ↓	0
ncor1^b	Nuclear receptor corepressor 1	2 ↑	0
ncor2^b	Nuclear receptor corepressor 2	2 ↑, 2 ↓	0
pak2b^b	p21 protein (Cdc42/Rac)-activated kinase 2b	2 ↓	0
phc2a^a	Polyhomeotic homolog 2a	2 ↓	1 ↑, 1 ↓
prkcbb^b	Protein kinase C beta b	2 ↓	0
raraa^b	Retinoic acid receptor, alpha a	2 ↑	0
rarab^b	Retinoic acid receptor, alpha b	1 ↑, 3 ↓	0
psme4b^a	Proteasome activator subunit 4b	1 ↑, 1 ↓	1 ↑
cnr1^a	Cannabinoid receptor 1	1 ↓	1 ↓
rfx2^a	Regulatory factor X, 2	2 ↓	2 ↓
alkbh1	AlkB homolog 1, histone H2A dioxygenase	0	2 ↑, 2 ↓
DNA methylation
dnmt3aa^b	DNA (cytosine-5-)-methyltransferase 3 alpha a	1 ↑	0
dnmt3ab^b	DNA (cytosine-5-)-methyltransferase 3 alpha b	2 ↓	0
dnmt3ba	DNA (cytosine-5-)-methyltransferase 3 beta a	1 ↓	1 ↑
ppm1db^a	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db	2 ↑	1 ↑

Numbers of DMSs and regions are shown with direction of methylation change.

^{^a}

Gene is associated with a DMS.

^{^b}

Gene is associated with a DMR.