. 2020 Sep 27;6(1):dvaa010. doi: 10.1093/eep/dvaa010

Table 6:

Genes both differentially methylated and differentially expressed in the F1 generation with roles in reproduction

Gene	Methylation		Gene expression		Function
	Percent change	P-value	Fold change	P-value
otud6b^a^,b	−24.2	9.38E−03	1.23	2.43E−02	Deubiquitinating enzyme; variants in this gene can cause Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features including cryptorchidism Santiago-Sim et al. (51)
	−12.0	1.37E−06
	−6.64	2.90E−03
dirc2^a^,b	−11.4	1.96E−02	1.23	4.32E−02	Membrane-bound electrogenic metabolite transporter; increased expression in prostate cancer tissue [Nesslinger et al. (85)]
dirc2^a^,b	−6.26	2.63E−03	1.23	4.32E−02
plxna4^a^,b	−14.7	4.10E−05	−1.2	2.58E−02	Involved in axon guidance, axonal defasciculation, and morphogenesis of a branching structure; also found to be differentially methylated with BPA exposure in zebrafish [Olsvik et al. (86)], lead exposure in human embryonic stem cells [Senut et al. (87)], and folic acid exposure in mouse [Barua et al. (88)]
	62.0	1.06E−08
	−9.25	6.45E−03
	22.8	8.52E−06
	−10.4	4.71E−03
	−10.4	4.71E−03
	−6.19	2.86E−02
	−5.69	4.62E−02
	58.4	2.68E−15
	58.4	2.68E−15
rhoub^a^,b	9.52	2.44E−03	1.31	4.38E−02	Upstream regulator of the actin cytoskeleton through PAK1 and can initiate cell cycle reentry of quiescent cells; endometriosis (GWAS)
rhoub^a^,b	−10.3	6.46E−03	1.31	4.38E−02
sall1a^a,b	−22.9	3.40E−04	1.8	3.25E−02	Positive regulation of fibroblast growth factor receptor signaling pathway, cryptorchidism, abnormal testis morphology (GWAS)
	11.7	3.44E−03
	11.7	3.44E−03
	−9.76	2.21E−02
	−9.76	2.21E−02
	−6.40	1.24E−02
	−6.32	7.73E−04
	−5.81	1.85E−03
	6.61	3.69E−03
xpa^b	7.90	2.20E−02	−1.82	4.35E−02	Nucleotide excision repair protein; decreased expression associated with defects in spermatogenesis Nakane et al. (53) and Singh et al. (54)
arrb1^b	13.6	1.71E−03	1.25	1.39E−02	Nucleotide excision repair protein; decreased expression associated with defects in spermatogenesis Nakane et al (53) and Singh et al. (54) Cofactor in the beta-adrenergic receptor kinase-mediated desensitization of beta-adrenergic receptors; involved in FSH signaling pathway
arrb1^b	6.98	2.20E−02	1.25	1.39E−02
acox1^a^,b	17.9	2.40E−03	10.7	7.12E−03	Fatty acid beta oxidation; necessary for fertility in mice Fan et al. (55)
	18.2	2.29E−02
	9.06	1.45E−03
	−10.1	7.30E−05
	−24.6	1.20E−03
	6.1	1.50E−02
	−10.5	4.87E−06
	−7.87	3.40E−03
ptena^a	5.37	1.12E−02	1.17	3.19E−02	Involved in gonadal development
ptena^a	5.37	1.12E−02	1.17	3.19E−02	Involved in gonadal development

All DMSs and/or DMRs are listed.

^{^a}

Gene is associated with a DMR.

^{^b}

Gene is associated with a DMS.