Figure 7.

Proposed Mechanism of Ribosome Biogenesis Regulation by LARP6-Dependent RP-mRNA Localization

For a Figure360 author presentation of this figure, see https://doi.org/10.1016/j.devcel.2020.10.006.

LARP6 binds RP-mRNAs and localizes them to the protrusive fronts of migrating mesenchymal-like cells, where their translation is enhanced due to the local enrichment of active translation machinery. Once translated, nascent RPs transport back to the nucleus to participate in ribosome biogenesis, leading to increased ribosome production and augmented overall protein synthesis.