. 2020 Jun 23;49(4):1353–1365. doi: 10.1093/ije/dyaa099

Table 3.

Cox proportional hazards models of BMI at baseline and subsequent dementia

	Hazard ratios (95% confidence interval)
	Model 1^a	Model 2	Model 3	Model 4
BMI
Normal (Ref^b)	1	1	1	1
Overweight	1.24 (1.00, 1.48)	1.25 (1.01, 1.49)	1.29 (1.05, 1.53)^*	1.27 (1.03, 1.51)^*
Obese	1.35 (1.09, 1.61)^*	1.31 (1.04, 1.58)^*	1.34 (1.07, 1.61)^*	1.31 (1.03, 1.59)^*
Age (Continuous)	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***
Sex
Men (Ref)	1	1	1	1
Women	0.86 (0.66, 1.06)	0.78 (0.57, 0.99)^*	0.79 (0.58, 1.00)^*	0.80 (0.59, 1.01)^*
APOE ɛ4 carrier
No (Ref)	1	1	1	1
Yes	2.33 (2.13, 2.53)^***	2.35 (2.15, 2.55)^***	2.34 (2.14, 2.54)^***	2.33 (2.13, 2.53)^***
Education
No qualifications (Ref)		1	1	1
A-level		0.87 (0.65, 1.09)	0.91 (0.69, 1.13)	0.89 (0.67, 1.11)
Degree		0.63 (0.34, 0.92)^**	0.67 (0.38, 0.96)^**	0.67 (0.38, 0.96)^**
^*Marital status
Married (Ref)		1	1	1
Unmarried		1.09 (0.87, 1.31)	1.06 (0.84, 1.28)	1.06 (0.84, 1.28)
Physical activity
Yes (Ref)			1	1
No			1.38 (0.99, 1.77)	1.34 (0.95, 1.73)
Smoker status
Non-smoker (Ref)			1	1
Current smoker			1.73 (1.43, 2.03)^***	1.70 (1.40, 2.00)^***
Hypertension diagnosed
No (Ref)				1
Yes				0.91 (0.71, 1.11)
Diabetes diagnosed
No (Ref)				1
Yes				1.38 (1.10, 1.66)^*
Observations	6582	6582	6582	6582

P< 0.05;

^**

P < 0.01;

^***

P < 0.001.

Model 1 adjusted for age, sex and APOE ɛ4 at baseline. Model 2 based on Model 1 further adjusted for education and marital status at baseline. Model 3 based on Model 2 further adjusted for smoking status and physical activity at baseline. Model 4 based on Model 3 further adjusted for hypertension and diabetes at baseline.

Ref, reference group.