Table 5.
Cox proportional hazards models of men WC at baseline and subsequent dementia
| Hazard ratios (95% confidence interval) |
||||
|---|---|---|---|---|
| Model 1a | Model 2 | Model 3 | Model 4 | |
| WC | ||||
| Normal (Refb) | 1 | 1 | 1 | 1 |
| Abdominal obesity | 0.86 (0.57, 1.15) | 0.84 (0.55, 1.13) | 0.85 (0.56, 1.14) | 0.84 (0.55, 1.13) |
| Age (continuous) | 1.13 (1.11, 1.15)*** | 1.12 (1.10, 1.14)*** | 1.13 (1.11, 1.15)*** | 1.13 (1.11, 1.15)*** |
| APOE ɛ4 carrier | ||||
| No (Ref) | 1 | 1 | 1 | 1 |
| Yes | 2.19 (1.89, 2.49)*** | 2.24 (1.94, 2.54)*** | 2.22 (1.92, 2.52)*** | 2.21 (1.91, 2.51)*** |
| Education | ||||
| No qualification (Ref) | 1 | 1 | 1 | |
| A-level | 0.83 (0.51, 1.15) | 0.87 (0.55, 1.19) | 0.84 (0.52, 1.16) | |
| Degree | 0.40 (0.26, 0.61)*** | 0.42 (0.28, 0.63)*** | 0.41 (0.27, 0.62)*** | |
| Marital status | ||||
| Married (Ref) | 1 | 1 | 1 | |
| Unmarried | 1.06 (0.73, 1.39) | 1.04 (0.71, 1.37) | 1.02 (0.69, 1.35) | |
| Physical activity | ||||
| Yes (Ref) | 1 | 1 | ||
| No | 1.11 (0.42, 1.80) | 1.02 (0.33, 1.70) | ||
| Smoker status | ||||
| Non-smoker (Ref) | 1 | 1 | ||
| Current smoker | 1.56 (1.12, 2.00) | 1.55 (1.11, 1.99) | ||
| Hypertension diagnosed | ||||
| No (Ref) | 1 | |||
| Yes | 0.87 (0.58, 1.16) | |||
| Diabetes diagnosed | ||||
| No (Ref) | 1 | |||
| Yes | 1.48 (1.08, 1.88) | |||
| Observations | 2515 | 2515 | 2515 | 2515 |
*
P < 0.05;
**
P < 0.01;
***
P < 0.001.
a
Model 1 Adjusted for age and APOE ɛ4 at baseline. Model 2 based on Model 1 further adjusted for education and marital status at baseline. Model 3 based on Model 2 further adjusted for smoking status and physical activity at baseline. Model 4 based on Model 3 further adjusted for hypertension and diabetes at baseline.
b
Ref, reference group.