. 2020 Jun 23;49(4):1353–1365. doi: 10.1093/ije/dyaa099

Table 6.

Cox proportional hazards models of BMI and WC measures at baseline and subsequent dementia

	Hazard ratios (95% confidence interval)
	Model 1^a	Model 2	Model 3	Model 4
Normal BMI + WC (Ref)	1	1	1	1
Normal BMI + high WC	1.07 (0.33, 1.81)	1.09 (0.35, 1.83)	1.01 (0.26, 1.76)	1.01 (0.26, 1.76)
Obese+ normal WC	1.28 (0.99, 1.57)	1.30 (1.01, 1.59)	1.33 (1.04, 1.62)	1.32 (1.03, 1.61)
Obese+ high WC	1.31 (1.07, 1.55)^*	1.30 (1.06, 1.54)^*	1.31 (1.07, 1.55)^*	1.28 (1.03, 1.53)^*
Age (continuous)	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***	1.14 (1.13, 1.15)^***
Sex
Men (Ref)	1	1	1	1
Women	0.86 (0.66, 1.06)	0.79 (0.58, 1.00)^*	0.79 (0.58, 1.00)^*	0.81 (0.60, 1.02)^*
APOE ɛ4 carrier
No (Ref)	1	1	1	1
Yes	2.34 (2.14, 2.54)^***	2.36 (2.16, 2.56)^***	2.35 (2.15, 2.55)^***	2.34 (2.14, 2.54)^***
Education
No qualifications (Ref)		1	1	1
A-level		0.88 (0.66, 1.10)	0.92 (0.69, 1.15)	0.90 (0.67, 1.13)
Degree		0.64 (0.35, 0.93)^**	0.67 (0.38, 0.96)^**	0.67 (0.38, 0.96)^**
Marital status
Married (Ref)		1	1	1
Unmarried		1.09 (0.87, 1.31)	1.06 (0.84, 1.28)	1.05 (0.83, 1.27)
Physical activity
Yes (Ref)			1	1
No			1.41 (1.02, 1.99)	1.37 (0.98, 1.76)
Smokers status
Non-smokers (Ref)			1	1
Current smokers			1.68 (1.37, 1.99)^***	1.65 (1.34, 1.96)^**
Hypertension diagnosed
No (Ref)				1
Yes				0.92 (0.72, 1.12)
Diabetes diagnosed
No (Ref)				1
Yes				1.41 (1.13, 1.69)^*
Observations	5353	5353	5353	5353

P < 0.05;

^**

P < 0.01;

^***

P < 0.001.

Model 1 Adjusted for age, sex and APOE ɛ4 at baseline. Model 2 based on Model 1 further adjusted for education and marital status at baseline. Model 3 based on Model 2 further adjusted for smoking status and physical activity at baseline. Model 4 based on Model 3 further adjusted for hypertension and diabetes at baseline.

Ref, reference group.