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Reagents and conditions: (a) BocNH(CH2)nNH2, DME, NEt3, 80 °C, 66% (n = 2) or 91% (n = 4); (b) NaH, propargylbromide, THF, 4 °C, 60% or 68%; (c) 6, Pd(PPh3)4, CuI, NEt3, THF, 60 °C, 37% or 40%; (d) 28% NH4OH/MeOH, rt; TFA/H2O, 4 °C, 42% or 61% in two steps.
