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. Author manuscript; available in PMC: 2020 Nov 12.
Published in final edited form as: Cell Rep. 2020 Oct 27;33(4):108270. doi: 10.1016/j.celrep.2020.108270

Figure 4. SpDNV Eliminates All Metabolic-Proven Effects of RYGB.

Figure 4.

(A) Average weekly body weight in g of RYGB-operated DIO mice with and without selective splanchnic denervation (SpDNV) compared with their sham counterparts.

(B) Change in body weight (g/day) over 5 weeks after RYGB.

(C) Average daily food intake.

(D) Feeding efficiency (expressed as mg of body weight gain per kJ consumed).

(E) Fat and lean mass—assessed by NMR—before and after surgeries.

(F–I) Total energy expenditure (F and G), O2 consumption (H), and respiratory exchange ratio (RER) (I) were all obtained from measurements taken during the CLAMS system using respirometry or indirect calorimetry in free-moving animals.

(J and K) Oral glucose tolerance test (J) and insulin tolerance test (K) performed during post-operative week 4 or 5 in RYGB- and sham-operated mice with or without SpDNV. Mean ± SEM. Sham n = 11, RYGB n = 9, sham + SpDNV n = 8, RYGB + SpDNV n = 9. ANOVA followed by Tukey’s test. *, #, $p < 0.05; $ $, &&p < 0.01; ***, $ $ $p < 0.001. *Sham versus RYGB; #sham + SpDNV versus RYGB + SpDNV; $sham versus sham + SpDNV; &RYGB versus RYGB + SpDNV.