Table 4.
Enriched Biological Functions of the 418 Significant Tumor-Downregulated Genes Identified from BP's Tumor Sample
| Term Category | Enriched Terms | First Hit Term Description | q Value |
|---|---|---|---|
| GO: MF | 25 | monovalent inorganic cation transmembrane transporter activity | 1.832 × 10−8 |
| GO: BP | 78 | ion transport | 3.206 × 10−12 |
| GO: CC | 7 | intrinsic component of plasma membrane | 1.572 × 10−14 |
| Human phenotype | 7 | abnormal circulating renin | 8.091 × 10−6 |
| Mouse phenotype | 24 | abnormal urination | 2.289 × 10−9 |
| Pathway | 2 | ensemble of genes encoding extracellular matrix and associated proteins | 3.552 × 10−6 |
| PubMed | 56 | activation of hypoxia signaling in stromal progenitors impairs kidney developmenta | 3.805 × 10−15 |
| Coexpression atlas | 398 | Kidney | 5.459 × 10−40 |
| TopCell atlas | 83 | epithelial—ts14 kidney of epithelial | 7.531 × 10−24 |
| Computational | 3 | heart, liver, kidney, and pancreas metabolic and xenobiotic response gene. | 4.467 × 10−7 |
| Disease | 4 | nephrocalcinosis | 4.656 × 10−6 |
a
Second ToppFun enrichment hit, noted because the first hit was a PubMed article relevant to mouse phenotype rather than human.