Table 1. Structures of tyrosine kinase inhibitors used in this study.
Drug Code | Structure | Class of Inhibitor | Most active kinase |
---|---|---|---|
47F | Imatinib-Analog | Aurora A kinase | |
23D | Staurosporine | Broad spectrum kinase inhibitor | |
32C | No syk activity | CDC7, promiscuous | |
32D | No syk activity | MAP2K1, promiscuous | |
32A3 | No syk activity | CDK9, promiscuous | |
32E | Syk inhibitor IV | Syk | |
47H | Syk inhibitor R406 | Syk | |
47A3 | Syk inhibitor IV analog | Syk, PI-3 kinase | |
26D | Syk inhibitor IV analog | Syk, PI-3 kinase | |
23B3 | Proprietary structure | No syk activity | CDC7, promiscuous |