Table 2. Predicted upstream regulators of 278 differentially expressed genes identified in the transcriptome of splenic myeloid cells from hamsters with VL.
| Upstream Regulator (Gene symbol) | Fold change | Activation Z- score | p-value | Targets | Regulators |
|---|---|---|---|---|---|
| CSF2 | 6.4 | 3.0 | 4.10E-18 | 36 | 165 (18) |
| TLR4 | 2.4 | 2.8 | 2.50E-22 | 37 | 165 (20) |
| IFNG | 11.1 | 2.4 | 3.09E-46 | 95 | 174 (19) |
| CALCA | 3.1 | 2.2 | 3.49E-08 | 11 | 157 (18) |
| HRAS | 7.2 | 2.1 | 1.78E-25 | 49 | 184 (24) |
| IL4 | 10.6 | 2.1 | 5.95E-22 | 52 | 157 (17) |
| FPR2 | 3.3 | 2.0 | 2.64E-05 | 4 | 148 (20) |
| JUNB | 4.4 | 1.8 | 4.68E-14 | 18 | 183 (16) |
| IL6 | 5.0 | 1.9 | 9.23E-38 | 67 | 173 (17) |
Colony stimulating factor 2 (CSF2); toll like receptor 4 (TLR4); interferon gamma (IFNG); calcitonin related polypeptide alpha (CALCA); HRas proto-oncogene (HRAS); interleukin 4 (IL4); JunB proto-oncogene (JUNB); formyl peptide receptor 2 (FPR2); interleukin 6 (IL6). Activation Z-score given by the number of gene targets in data set (Predicted with IPA).