Table 3. Differentially expressed proto-oncogenes and tumor suppressor genes identified in the transcriptome of splenic myeloid cells from hamsters with VL.
| Gene Symbol | Fold Change | Family |
|---|---|---|
| Proto-oncogenes | ||
| HRAS | 7.2 | GTPase enzyme |
| JUNB | 4.4 | AP1 transcription factor subunit |
| MYB | 4.1 | transcription regulator |
| FGR | 3.8 | Kinase (Src family tyrosine kinase) |
| FYN | 3.8 | Kinase (Src family tyrosine kinase) |
| SRC | 3.8 | Kinase (non-receptor tyrosine kinase) |
| CBL | 2.1 | transcription regulator |
| CBLB | 2.1 | Enzyme |
| ROS1 | 2.0 | Kinase (receptor tyrosine kinase) |
| FES | -5.1 | Kinase (tyrosine kinase) |
| FOSB | -5.2 | AP-1 transcription factor subunit |
| BLK | -6.1 | Kinase (Src family tyrosine kinase) |
| Tumor suppressor genes | ||
| VHL | -10.6 | transcription regulator |
| RPL10 | -4.3 | Other |
HRas proto-oncogene (HRAS); JunB proto-oncogene, AP1 transcription factor subunit (JUNB); MYB proto-oncogene (MYB); FGR proto-oncogene (FGR); FYN proto-oncogene (FYN); SRC proto-oncogene (SRC); Cbl proto-oncogene (CBL); Cbl proto-oncogene B (CBLB); ROS proto-oncogene 1 (ROS1); FES proto-oncogene (FES); FosB proto-oncogene (FOSB); BLK proto-oncogene (BLK); von Hippel-Lindau tumor suppressor (VHL); ribosomal protein L10 (RPL10). Differentially expressed genes (FDR<0.05 and a fold change of 2.0, with reference to uninfected).