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. 2020 Oct 23;21(21):7887. doi: 10.3390/ijms21217887

Figure 2.

Figure 2

Protein expressions of endothelial cell functional integrity and gene expression of endothelial nitric-oxide synthase (eNOS) in CLI zone by day 28 after CLI procedure. (A) Protein expression of CD31, * vs. other groups with different symbols (†, ‡, §), p < 0.0001; (B) Protein expression of von Willebrand factor (vWF), * vs. other groups with different symbols (†, ‡, §), p < 0.0001; (C) Protein expression of eNOS, * vs. other groups with different symbols (†, ‡, §), p < 0.0001; (D) mRNA expression of eNOS, * vs. other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses are performed by one-way ANOVA, followed by the Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; CLI = critical limb ischemia; EPC = endothelial progenitor cells; EPCPr-T = EPCs derived from severe PAOD patient’s circulatory blood prior to CD34+ cell and HBO treatment; EPCAf-T = EPCs derived from severe PAOD patient’s circulatory blood after CD34+ cell and HBO treatment; PAOD = peripheral arterial occlusive disease; HBO = hyperbaric oxygen.