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Illustrating the proposed underlying mechanism for rejuvenated xenogeneic EPCs effectively salvaging nude mouse limbs from CLI. CLI = critical limb ischemia; EPC = endothelial progenitor cells; EPCPr-T = EPCs derived from severe PAOD patient’s circulatory blood prior to CD34+ cell and HBO treatment; EPCAf-T = EPCs derived from severe PAOD patient’s circulatory blood after CD34+ cell and HBO treatment.
