Figure 1.

Bland‐Altman plot depicting the heterogeneity in associations with mean arterial blood pressure (MAP) at age ≤55 and >55 years for the variants identified as having genome‐wide significant association with either trait in analyses considering the whole UK Biobank cohort.

For each variant, the x axis depicts the mean of the association with MAP at age ≤55 and >55 years, and the y axis represents the difference in association with MAP at age ≤55 and >55 years. The dashed lines depict 10th and 90th percentiles of the expected distribution of heterogeneity statistics under the null hypothesis of homogeneity (ie, the interdecile range). A total of 34 variants (colored black rather than gray) fall outside this and were used in model 3 of the multivariable mendelian randomization.