Table 3.

Sensitivity Analysis Using PDE‐5 Inhibitor as a Time‐Varying Covariate

End Point	PDE‐5 Inhibitor vs No PDE‐5 Inhibitor	P Value
	Adjusted Hazard Ratioa (95% CI)
Pump thrombosis or ischemic stroke (primary end point)	0.54 (0.45–0.66)	<0.001
Pump thrombosis	0.45 (0.35–0.57)	<0.001
Ischemic stroke	0.70 (0.51–0.96)	0.028
All‐cause mortality	0.43 (0.35–0.53)	<0.001
All‐cause mortality, pump thrombosis, or ischemic stroke	0.50 (0.44–0.58)	<0.001

PDE‐5 indicates phosphodiesterase type 5.

^aEach end point model is adjusted for the significant variables listed in Table S3.