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. 2020 Oct 25;85(21):14174–14189. doi: 10.1021/acs.joc.0c01699

Figure 1.

Figure 1

(A) Bicyclic 2-pyridones capable of modulating (compounds 13) and binding (compound 4) to α-synuclein and amyloid β fibrils. (B) Chromenopyridine containing bioactive polyheterocycles 58 and retrosynthetic strategy devised for construction of chromenopyridine fused 2-pyridone polyheterocycle 11.