Table 1.
Health Status Measurements at Baseline and 12 Months and the Change Over Time Using KCCQ, EQ‐5D, and FACT‐An
| Controls | At‐Risk | HFpEF | HFrEF | P Value | |
|---|---|---|---|---|---|
| N* | 98 | 163 | 191 | 169 | |
| KCCQ CSS, median (IQR) | |||||
| Baseline | 100 (97, 100) | 95 (85, 100) | 73 (55, 90) | 82 (61, 92) | <0.0001 |
| 12‐mo | 100 (100, 100) | 96 (84, 100) | 71 (56, 88) | 80 (64, 93) | <0.0001 |
| Δ KCCQ CSS, n (%) | |||||
| Decrease | 1 (3.8) | 23 (21.5) | 49 (34.8) | 33 (28.0) | <0.0001 |
| No change | 24 (92.3) | 64 (59.8) | 50 (35.5) | 53 (44.9) | |
| Increase | 1 (3.8) | 20 (18.7) | 42 (29.8) | 32 (27.1) | |
| KCCQ OSS, median (IQR) | |||||
| Baseline | 100 (98, 100) | 95 (85, 99) | 73 (53, 86) | 78 (56, 90) | <0.0001 |
| 12‐mo | 100 (100, 100) | 96 (84, 100) | 71 (53, 89) | 79 (56, 91) | <0.0001 |
| Δ KCCQ OSS, n (%) | |||||
| Decrease | 1 (3.8) | 19 (17.8) | 52 (36.9) | 32 (27.1) | <0.0001 |
| No change | 22 (84.6) | 71 (66.4) | 50 (35.5) | 46 (39.0) | |
| Increase | 3 (11.5) | 17 (15.8) | 39 (27.7) | 40 (33.9) | |
| FACT‐An, median (IQR) | |||||
| Baseline | 172 (160, 177) | 158 (137, 168) | 133 (110, 154) | 137 (112, 157) | <0.0001 |
| 12‐mo | 178 (167, 183) | 157 (137, 171) | 135 (112, 153) | 140 (117, 160) | <0.0001 |
| Δ FACT‐An, n (%) | |||||
| Decrease | 2 (25.0) | 22 (29.0) | 40 (32.8) | 22 (21.2) | 0.38 |
| No change | 4 (50.0) | 32 (42.0) | 45 (36.9) | 39 (37.5) | |
| Increase | 2 (25.0) | 22 (29.0) | 37 (30.3) | 43 (41.3) | |
| EQ‐5D, median (IQR) | |||||
| Baseline | 90 (80, 95) | 80 (70, 90) | 70 (55, 80) | 70 (50, 80) | <0.0001 |
| 12‐mo | 90 (85, 95) | 80 (70, 90) | 70 (50, 80) | 70 (50, 80) | <0.0001 |
| ΔEQ‐5D, n (%) | |||||
| Decrease | 1 (3.6) | 22 (24.5) | 46 (38.0) | 28 (27.2) | <0.0001 |
| No change | 25 (89.3) | 47 (52.2) | 45 (37.2) | 38 (36.9) | |
| Increase | 2 (7.1) | 21 (23.3) | 30 (24.8) | 37 (35.9) | |
CSS indicates KCCQ clinical summary score; EQ‐5D, EuroQOL 5 dimensions questionnaire; FACT‐An, Functional Assessment of Cancer Therapy—Anemia; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HRQoL, health‐related quality of life; IQR, interquartile range; KCCQ, Kansas City Cardiomyopathy Questionnaire; N, number; OSS, KCCQ overall summary score; SD, standard deviation; and Δ, change.
a
Data on availability of HRQoL measurements is provided in Table S4.