Figure 9.

Summary of the current understanding of the mechanisms of interatrial shunts and the studies that generated data to support these findings.AFR indicates atrial flow regulator; HF, heart failure; LA, left atrial; O₂, oxygen; PA, pulmonary artery; PCWP, pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; REDUCE LAP‐HF, Reduce Elevated Left Atrial Pressure in Patients With Heart Failure; Qp:Qs, ratio of pulmonary to systemic blood flow; RAP, right atrial; and RELIEVE‐HF, Reducing Lung Congestion Symptoms in Advanced Heart Failure. Refer to Table 1 for study details and references.