Figure 3. Tonic reactive oxygen species‐mediated suppression of endothelial function.

Brachial artery flow‐mediated dilation (FMD_BA) following intravenous infusion of saline and vitamin C in midlife/older adults classified according to 2017 American College of Cardiology/American Heart Association guidelines. Data are expressed as percent change (∆%) from baseline diameter. Box indicates interquartile range and median, whiskers indicate 5th to 95th percentiles. Normal blood pressure (BP): n=100; elevated BP: n=34; stage 1 hypertension: n=64; stage 2 hypertension: n=36. *P<0.05 compared with saline condition.