Table 3.
Adjusted Association Between Gait Speed at 1 Year or Change From Baseline With Clinical Outcomes Between 1 and 2 Years Post‐TAVR
| Mortality or Hospitalization | Mortality | Hospitalization | ||||
|---|---|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Adjusted models for normal vs slow gait speed at baseline and 1 y* | ||||||
| Normal baseline/normal 1 y (referent) | 1.0 | … | 1.0 | … | 1.0 | … |
| Slow baseline/normal 1 y | 1.38 [0.54–3.50] | 0.50 | 1.48 [0.51–4.28] | 0.47 | 2.01 [0.48–8.48] | 0.34 |
| Normal baseline/slow 1 y | 3.64 [1.53–8.68] | 0.004 | 2.53 [0.88–7.27] | 0.09 | 7.05 [1.86–26.69] | 0.004 |
| Slow baseline/slow 1 y | 3.40 [1.61–7.18] | 0.001 | 2.69 [1.11–6.51] | 0.03 | 4.04 [1.18–13.92] | 0.03 |
| Adjusted models for magnitude and direction of change in gait speed between baseline and 1 y† | ||||||
| Large worsening in gait speed from baseline to 1 y | 2.05 [1.06–3.99] | 0.03 | 1.66 [0.67–4.10] | 0.27 | 2.68 [1.15–6.27] | 0.02 |
| Small worsening in gait speed from baseline to 1 y | 1.05 [0.48–2.30] | 0.91 | 1.25 [0.48–3.25] | 0.64 | 0.80 [0.23–2.76] | 0.73 |
| No change in gait speed from baseline to 1 y | 1.0 | … | 1.0 | … | 1.0 | … |
| Small improvement in gait speed from baseline to 1 y | 0.50 [0.21–1.19] | 0.12 | 0.47 [0.14–1.63] | 0.24 | 0.45 [0.13–1.53] | 0.20 |
| Large improvement in gait speed from baseline to 1 y | 0.65 [0.35–1.20] | 0.17 | 0.92 [0.43–1.98] | 0.84 | 0.52 [0.21–1.25] | 0.14 |
| Adjusted models for 1 y gait speed‡ | ||||||
| 1‐y gait speed (per 0.1 increase) | 0.83 [0.74–0.93] | 0.001 | 0.91 [0.80–1.04] | 0.18 | 0.76 [0.65–0.89] | 0.0007 |
| Baseline gait speed (per 0.1 increase) | 0.96 [0.87–1.07] | 0.48 | 0.97 [0.84–1.10] | 0.61 | 0.99 [0.86–1.14] | 0.85 |
aHR indicates adjusted hazard ratio; and TAVR, transcatheter aortic valve replacement.
*
Each model adjusted for the variables in the selection model: age (at time of consent), subject currently taking immunosuppressive therapy, female sex, history of chronic obstructive pulmonary disease, medically treated diabetes mellitus, mean aortic valve gradient at baseline, and stroke through 365 days.
†
Each model adjusted for variables in the selection model+baseline gait speed.
‡
Each model adjusted for variables in the selection and included both baseline and 1 year gait speed.