Table 1.
Baseline Characteristics of Study Population at MESA Exam 1 by APOL1 Risk Status
| Characteristic | All (n=1619) | APOL1 high‐risk (n=190) | APOL1 low‐risk (n=1429) |
|---|---|---|---|
| Age, y | 62±10 | 62±9 | 62±10 |
| Female | 876 (54) | 96 (51) | 780 (55) |
| Education | |||
| Less than high school | 180 (11) | 25 (13) | 155 (11) |
| High school graduate | 312 (19) | 32 (17) | 280 (20) |
| Postsecondary | 1116 (69) | 132 (70) | 984 (69) |
| Employment | |||
| Employed | 658 (41) | 76 (40) | 582 (41) |
| Unemployed/employed part‐time | 125 (8) | 18 (10) | 107 (8) |
| Retired/homemaker | 824 (51) | 95 (50) | 729 (51) |
| Annual family income | |||
| <$25 000 | 437 (29) | 49 (28) | 388 (29) |
| $25 000–$49 999 | 486 (33) | 57 (33) | 429 (32) |
| $50 000–$74 999 | 310 (21) | 35 (20) | 275 (21) |
| ≥$75 000 | 263 (18) | 32 (19) | 231 (18) |
| Smoking status | |||
| Never | 738 (46) | 84 (44) | 654 (46) |
| Former | 579 (36) | 67 (35) | 512 (36) |
| Current | 291 (18) | 38 (20) | 253 (18) |
| Diabetes mellitus | 274 (17) | 40 (21) | 234 (16) |
| Fasting glucose, mg/dL | 100±32 | 102±32 | 100±32 |
| Hypertension | 946 (58) | 119 (63) | 827 (58) |
| Systolic BP, mm Hg | 131±21 | 132±21 | 131±21 |
| Diastolic BP, mm Hg | 75±10 | 74±10 | 75±10 |
| Pulse pressure, mm Hg | 57±17 | 58±18 | 57±17 |
| Antihypertensive medication use | 802 (50) | 104 (55) | 698 (49) |
| Total cholesterol, mg/dL | 190±36 | 190±37 | 190±36 |
| Triglycerides, mg/dL | 89 [66–122] | 88 [65–122] | 89 [66–122] |
| HDL, mg/dL | 52±15 | 54±16 | 52±15 |
| LDL, mg/dL | 117±33 | 116±35 | 117±33 |
| Lipid‐lowering medication use | 253 (16) | 33 (17) | 220 (15) |
| Body mass index, kg/m2 | 30.1±5.8 | 30.1±6.0 | 30.1±5.7 |
| Moderate‐vigorous PA, MET‐min/wk | 4613 [2160–8588] | 4455 [2135–8370] | 4636 [2160–8678] |
| Family history of heart disease | 634 (42) | 63 (35) | 571 (43) |
| eGFRCysC, mL/min/1.73 m2 | 90±20 | 90±19 | 90±20 |
| UACR, mg/g | 5.3 [3.1–12.0] | 5.5 [3.3–14.5] | 5.2 [3.0–11.9] |
| UACR ≥30 | 170 (11) | 27 (14) | 143 (10) |
Values presented as mean±SD, median [interquartile range], or number (percentage). BP, blood pressure; eGFRCysC, estimated glomerular filtration rate based on cystatin C; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MESA, Multi‐Ethnic Study of Atherosclerosis; MET, metabolic equivalent; PA, physical activity; and UACR, urine albumin‐to‐creatinine ratio.