Table 2.
Association of APOL1 Risk Status With Subclinical Measures of Vascular and Endothelial Function at MESA Exam 1
| C2 | ||||
|---|---|---|---|---|
| n |
Mean (SD) mL/mm Hg×100 |
Model 1 β (95% CI) |
Model 2 β (95% CI) |
|
| APOL1 low‐risk | 1393 | 4.20 (2.55) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high‐risk | 193 | 4.01 (2.30) | −0.15 (−0.55, 0.25) | −0.11 (−0.47, 0.24) |
| P value | 0.33 | 0.47 | 0.54 | |
| C1 | ||||
|---|---|---|---|---|
| n |
Mean (SD) mL/mm Hg×10 |
Model 1 β (95% CI) |
Model 2 β (95% CI) |
|
| APOL1 low‐risk | 1393 | 13.49 (5.88) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high‐risk | 193 | 13.41 (2.10) | −0.06 (−0.98, 0.86) | −0.05 (−0.88, 0.78) |
| P value | 0.85 | 0.90 | 0.91 | |
| AAD | ||||
|---|---|---|---|---|
| n |
Mean (SD) mm Hg−1×103 |
Model 1 β (95% CI) |
Model 2 β (95% CI) |
|
| APOL1 low‐risk | 863 | 1.69 (1.31) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high‐risk | 122 | 1.55 (0.75) | −0.22 (−0.48, 0.04) | −0.21 (−0.46, 0.03) |
| P value | 0.09 | 0.10 | 0.09 | |
| FMD | ||||
|---|---|---|---|---|
| N |
Mean (SD) mm |
Model 1 β (95% CI) |
Model 2 β (95% CI) |
|
| APOL1 low‐risk | 692 | 0.15 (0.10) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high‐risk | 85 | 0.16 (0.09) | 0.01 (−0.02, 0.03) | 0.01 (−0.02, 0.03) |
| P‐value | 0.58 | 0.50 | 0.56 | |
Model 1 unadjusted. Model 2 adjusted for age, sex, and African ancestry. AAD indicates ascending aortic distensibility; C1, large arterial elasticity; C2, small arterial elasticity; FMD, flow‐mediated dilation; and MESA, Multi‐Ethnic Study of Atherosclerosis.