Table 3.
Association of APOL1 Risk Status With Longitudinal BP Change From MESA Exams 1 to 5
| n |
Relative Annual Change % Change/Year (95% CI) |
Model 1 Between‐Group Difference |
Model 2 Between‐Group Difference |
|
|---|---|---|---|---|
| Systolic BP | ||||
| APOL1 low risk | 1429 | −0.10 (−0.20, −0.01) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high risk | 190 | −0.21 (−0.46, 0.04) | −0.11 (−0.38, 0.16) | −0.20 (−0.48, 0.09) |
| P value | 0.42 | 0.17 | ||
| Diastolic BP | ||||
| APOL1 low risk | 1429 | −0.63 (−0.71, −0.55) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high risk | 190 | −0.69 (−0.90, −0.49) | −0.06 (−0.28, 0.16) | −0.14 (−0.37, 0.09) |
| P value | 0.57 | 0.24 | ||
| Pulse pressure | ||||
| APOL1 low risk | 1429 | 0.56 (0.41, 0.71) | 0.00 (ref) | 0.00 (ref) |
| APOL1 high risk | 190 | 0.41 (0.01, 0.82) | −0.15 (−0.58, 0.28) | −0.25 (−0.71, 0.21) |
| P value | 0.50 | 0.28 | ||
Model 1 unadjusted. Model 2 adjusted for age, sex, and African ancestry. BP, blood pressure; MESA, Multi‐Ethnic Study of Atherosclerosis; and ref, referent.