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. 2020 Sep 18;9(17):e017055. doi: 10.1161/JAHA.119.017055

Figure 1. Sorbs2 (sorbin and SH3 domain‐containing 2) is a cardiac‐enriched intercalated disc and desmosome protein in mice.

Figure 1

A, Western blot analysis of Sorbs2 protein expression in different mouse tissues. B, Images of immunostaining using an anti‐Sorbs2 antibody and counterstained with 4′,6‐diamidino‐2‐phenylindole (DAPI) in sectioned wild‐type mouse hearts. Arrowheads indicate the intercalated disc. The arrows indicate Z‐disc localization. Red arrows indicate the perinucleus. Bar=20 μm. C, Immunostaining and pseudoline analysis of sectioned mouse hearts are shown, indicating that Sorbs2 protein mostly colocalizes with β‐catenin and plakoglobin (Pkg), but less with connexin 43 (Cx43). Bar=2 μm. MW indicates molecular weight.